Three PhD scholarships – Ion Transport Proteins in Control of Cancer Cell Behavior (IonTraC)


IonTraC is a Marie Curie Initial Training Network and a special focus will be on pancreatic cancer. The IonTraC group is a European research consortium funded within the Marie Curie Initial Training Network action. It is composed of 11 research units (9 academic and 2 industrial/SME partners) with long-standing, complementary expertise in transport physiology, biophysics, pathology, cell biology, pharmacology, optical imaging, experimental and clinical oncology. The overall aim of the IonTraC project is to comprehensively test the hypotheses that proteins involved in ion transport constitute novel diagnostic/therapeutic targets for pancreatic ductal adenocarcinoma (PDAC). IonTraC will provide structured PhD program with extensive focus on mobility and collaboration. The three PhD positions (each 3 years of duration) are affiliated with sections of Molecular Integrative Physiology and Cell and Developmental Biology at the Department of Bi-ology, University of Copenhagen, and groups lead by Ivana Novak, Stine F. Pedersen and Else K. Hoffmann.
 

Eligibility for participation in a Marie Curie Initial Training Network: Applicants for PhDs must be in the first 4 years after obtaining their Master´s degree (see above). Furthermore, at the time of selection by the host organization, researchers must not have resided or carried out their main activity (work, studies, etc.) in Denmark for more than 12 months in the 3 years immediately prior to their recruitment. Excellent com-mand of spoken and written English, communication skills, and team spirit are essential. Terms of appoint-ment and payment are in accordance with the agreement between the Danish Ministry of Finance and the Danish Federation of Professional Associations (AC). Moreover, the salary of the candidate will be in ac-cordance with the rules and regulations laid down in the Marie Curie Grant Agreement.
 

Project 1 is pH regulatory transporters in pancreatic ductal adenocarcinoma. The aim is to elucidate the roles in PDAC of the potent H+ and HCO3- transporters highly expressed in pancreatic ducts such as H+-ATPases, Na+/H+ exchangers and Na+-HCO3- cotransporters. Their function in PDAC progression will be stud-ied in relation to the micro-environment defined by hypoxia, low pHe, low glucose, low serum, high lactate. The PhD student will use advanced cell culture techniques, cell and molecular biological techniques and advanced bioimaging. Starting in May 2012.
 

Project 2 is Cl- and K+ channels in pancreatic ductal adenocarcinoma growth and chemotherapy re-sistance. The aim of this project is to elucidate the roles of Cl- channels (specifically cystic fibrosis trans-membrane conductance regulator, CFTR, and Ca2+ activated Cl- channels of the TMEM16 family) and TASK-2 K+ channels in PDAC. Particular focus will be on the roles of these channels in cell death/survival and prolif-eration balance as well as on their role in chemo-resistance. The student will use the techniques outlined in the above project as well as patch-clamp techniques. Starting in May 2012.
 

Project 3 is pH dependence of ion channels involved in pancreatic ductal adenocarcinoma progression. This project will explore the influence of an altered pH homeostasis on the functional properties of ion channels involved in PDAC progression. The project thereby constitutes the bridge between projects focus-ing on pH regulatory transport proteins and those centered on ion channels. To this end the PhD will use all available ion channel technologies, including cell culture, advanced bioimaging, including high-throughput techniques, and automated whole-cell patch-clamp techniques. Starting in September 2012.
 

For more information see IonTraC homepage http://www.iontrac.uni-muenster.de/
 

For the full advertisement, deadline and application procedure please follow the link: www.bio.ku.dk

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